Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
user
  1. Dashboard
  2. My Profile
  3. My Address
  4. My Orders
  5. Acro Membership
Login Register
Promotion
Recombinant Proteins ClearClear history
Recombinant Proteins CloseClose
Browse Products By Molecule Name a-zA-Z
TL1A Hot |GMP Cytokines Hot |FcRn Binding Kit (TR-FRET) New |Claudin 18.2
0
There is no goods in the shopping cart !
My Cart|Secure Checkout
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > ZNRF3

ZNRF3

Brief Information

Name:E3 ubiquitin-protein ligase ZNRF3
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

Product ListCompare or Buy

Product> Filter Results
By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
ZN3-H52H3 Human Human ZNRF3 protein, His Tag (MALS verified)
ZN3-H52H3-structure
ZN3-H52H3-sds
ACRO Quality

Part of Bioactivity data

ZN3-H52H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human ZNRF3, His Tag (Cat. No. ZN3-H52H3) on HISIK Biosensor, can bind Human R-Spondin 3 Protein, Fc Tag with an affinity constant of 16.05 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

Protocol
ZN3-H52H3-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Human R-Spondin 3 Protein, Fc Tag on Protein A Biosensor, can bind Human ZNRF3, His Tag (Cat. No. ZN3-H52H3) with an affinity constant of 10.9 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

ZNRF3,  Zinc/RING finger protein 3, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, RNF203

Background

The transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) is a negative feedback regulator of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6 and acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SZN-043 SZN-043; SZN-043双特异性融合蛋白; SZN-043 Bispecific Fusion Protein; SZN-043 (RSPO模拟物) Phase 1 Clinical Surrozen Inc Hepatitis, Alcoholic; Liver Cirrhosis Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Email
Email
order@acrobiosystems.com
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA
linkedin twitter facebook youtube

Leave a message

Copyright © 2017 ACROBiosystems. All Rights Reserved
|Related Links|Privacy Policy|Terms and Conditions|Legal|Sitemap