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CD45

Brief Information

Name:Leukocyte common antigen
Target Synonym:PTPRC,T200,CD45,Protein Tyrosine Phosphatase, Receptor Type C,CD45 Antigen,L-CA,Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide,Receptor-Type Tyrosine-Protein Phosphatase C,T200 Leukocyte Common Antigen,Leukocyte Common Antigen,T200 Glycoprotein,EC 3.1.3.48,CD45R,GP180,B220,LCA,LY5,Leukocyte Common Antigens,Protein Tyrosine Phosphatase Receptor Type C,EC:3.1.3.48
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Phase 3 Clinical

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Part of Bioactivity data

FABm007-01-Cell-based assay
 CD45 FACS

Flow cytometric analysis of Jurkat staining with PE-Labeled Monoclonal Anti-Human CD45 Antibody, Mouse IgG2a (Cat. No. FABm007-01) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).

FABm007-06-Cell-based assay
 CD45 FACS

Flow cytometric analysis of Human peripheral blood lymphocytes respectively staining with PerCP-CY5.5-Labeled Anti-Human CD45 Antibody, mouse IgG2a (AIRFS225-240625F1-Bulk) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 2.5e5 cells in a final volume of 100 µL), compared with isotype control antibody. PerCP-CY5.5 signal was used to evaluate the binding activity (QC tested).

CD5-M52H3-SPR
 CD45 SPR

Mouse CD45 protein, His Tag (Cat. No. CD5-M52H3) captured on CM5 chip via anti-His antibody can bind Human Galectin-1, Tag Free (Cat. No. GA1-H4113) with an affinity constant of 7.19 µM as determined in a SPR assay (Biacore 8K) (QC tested).

CD5-H52H8-BLI
 CD45 BLI

Loaded Human CD45, His Tag (Cat. No. CD5-H52H8) on HIS1K Biosensor, can bind Human Galectin-1, Tag Free (Cat. No. GA1-H4113) with an affinity constant of 3.0 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

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Synonym Name

CD45,PTPRC,L-CA,T200

Background

CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Immunomodulatory progenitor cell therapy (Celixir) Phase 3 Clinical Celixir Endomyocardial Fibrosis; Cardiomyopathies Details
I-131-Apamistamab BC8-I-131; BC-8; 131IBC8 Phase 3 Clinical Fred Hutchinson Cancer Research Center Neoplasms, Gonadal Tissue; Lymphoma, Mantle-Cell; Sezary Syndrome; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Lymphoma; Burkitt Lymphoma; Intraocular Lymphoma; Lymphoma, T-Cell; Lymphoma, Follicular; Waldenstrom Macroglobulinemia; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Cutaneous; Anemia, Sideroblastic; Angioimmunoblastic T-cell Lymphoma; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Mycosis Fungoides; Leukemia-Lymphoma, Adult T-Cell; Leukemia; Lymphoma, B-Cell, Marginal Zone; Lymphoma, T-Cell, Peripheral; Hematopoietic stem cell transplantation (HSCT); Neoplastic Cells, Circulating; Leukemia, Hairy Cell; Anemia, Refractory, with Excess of Blasts; Lymphoma, Large B-Cell, Diffuse; Lymphoma, B-Cell; Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic; Hodgkin Disease; Lymphoma, Large-Cell, Immunoblastic; Lymphomatoid Granulomatosis; Lymphoma, Extranodal NK-T-Cell; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma Details
At 211 MAb BC8-B10 Phase 2 Clinical Fred Hutchinson Cancer Research Center Neoplasms Details

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