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Flow Cytometry assay shows that Human B7-1, Mouse IgG2a Fc Tag (Cat. No. B71-H52A4) can bind to 293 cell overexpressing human CTLA-4. The concentration of Human B7-1 is 1 μg/mL (Routinely tested).
FACS analysis shows that the binding of Human B7-1, Mouse IgG2a Fc Tag (Cat. No. B71-H52A4) to 293 overexpressing CTLA-4 was inhibited by increasing concentration of neutralizing Anti-human CTLA-4 antibody. The concentration of Human B7-1 is 1 μg /mL. The IC50 is 5.5 μg/mL (Routinely tested).
Immobilized Human / Cynomolgus / Rhesus macaque CD28, Fc Tag (Cat. No. CD8-H525a) on CM5 Chip can bind Human B7-1, Mouse IgG2a Fc Tag (Cat. No. B71-H52A4) with an affinity constant of 2.72 μM as determined in a SPR assay (Biacore T200) (Routinely tested).
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Belatacept | LEA29Y; LEA-029; BMS-224818; L104EA29YIg | Approved | Bristol-Myers Squibb Company | Nulojix | United States | Rejection of renal transplantation | Bristol-Myers Squibb Company | 2011-06-15 | Rejection of renal transplantation; Diabetes Mellitus, Type 1; Proteinuria; Pancreatic neuroendocrine tumors (pNET); Arthritis, Rheumatoid; Delayed Graft Function; Rejection of organ transplantation; Rejection in heart transplantation; Kidney Failure, Chronic | Details |
| Abatacept | ONO-4164SC; BMS-188667SC; ONO-4164; BMS-188667 | Approved | Bristol-Myers Squibb Company | Orencia, 恩瑞舒 | United States | Arthritis, Rheumatoid | Bristol-Myers Squibb Company | 2005-12-23 | Anemia, Aplastic; Nephrotic Syndrome; Uveitis; Cardiovascular Diseases; Healthy Aging; Urticaria; Sjogren-Larsson Syndrome; Arthritis, Psoriatic; Colitis, Ulcerative; Arthralgia; Takayasu Arteritis; Lupus Erythematosus, Systemic; Psoriasis; Allergic asthma; Glomerulosclerosis, Focal Segmental; Shwachman-Diamond Syndrome; Mucopolysaccharidosis I; Lymphohistiocytosis, Hemophagocytic; Anemia, Sickle Cell; Thrombasthenia; Kostmann Syndrome; Behcet Syndrome; Vitiligo; Crohn Disease; Muscular Diseases; Granulomatous Disease, Chronic; Lung Diseases, Interstitial; Leukocyte-Adhesion Deficiency Syndrome; Inflammation; Common Variable Immunodeficiency; Myocarditis; Eye Diseases; Scleroderma, Diffuse; Arthritis; Hematologic Diseases; Coronavirus Disease 2019 (COVID-19); Myositis; Alopecia Areata; Immunoglobulin G4-Related Disease; Dermatomyositis; Giant Cell Arteritis; Diabetes Mellitus, Type 1; Polymyositis; Arthritis, Rheumatoid; Wiskott-Aldrich Syndrome; Myasthenia Gravis; Hematologic Neoplasms; Polychondritis, Relap | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Belatacept biosimilar (Alphamab) | KN-019 | Phase 2 Clinical | Suzhou Alphamab Co Ltd | Rejection of renal transplantation; Arthritis, Rheumatoid | Details |
| ORCA-010 | ORCA-010 | Phase 2 Clinical | Orca Therapeutics Bv | Prostatic Neoplasms | Details |
| Membrane bound ligand T-SIGn virus | NG-348 | Phase 1 Clinical | Akamis Bio Ltd | Neoplasms | Details |
| Chimeric antigen receptor T-cell therapy (Hunan Zhaotai Yongren Biotech) | Z-CTLs | Phase 1 Clinical | Hunan Zhaotai Yongren Biotech Co Ltd | Carcinoma, Non-Small-Cell Lung | Details |
| VDJ-142 | VDJ-142 | Phase 1 Clinical | Beijing Vdjbio Co Ltd | Arthritis, Rheumatoid; Lupus Erythematosus, Systemic; Inflammation | Details |
| Abatacept biosimilar (Dr. Reddy's Laboratories) | DRL-AB | Phase 1 Clinical | Dr.Reddy's Laboratories Ltd | Arthritis, Rheumatoid | Details |
| SG-1827 | SG1827; SG-1827 | Phase 1 Clinical | Hangzhou Sumgen Biotechnology Co Ltd | Solid tumours | Details |
| Recombinant human CTLA-4-FC fusion protein(Beijing Vdjbio) | Phase 1 Clinical | Beijing Vdjbio Co Ltd | Arthritis, Rheumatoid | Details |
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