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Your Position: Home > RON

RON

Brief Information

Name:Macrophage-stimulating protein receptor
Target Synonym:Ron tyrosine kinase receptor,MSP Receptor,PTK8,PTK8 Protein Tyrosine Kinase 8,Macrophage Stimulating 1 Receptor,MST1R,NPCA3,S13 Avian Erythroblastosis Oncogene Homolog,CDw136,CD136,CD136 Antigen,C-Met-Related Tyrosine Kinase,EC:2.7.10.1,EC 2.7.10.1,Protein-Tyrosine Kinase 8,S13 Erythroblastosis Oncogene Homolog,RON,SEA,Macrophage-Stimulating Protein Receptor,S13 Erythroblastosis (Avian) Oncogene Homolog,P185-Ron,EC 2.7.10
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
RON-H52H9 Human Human RON / MSPR Protein, His Tag (MALS verified)
RON-H52H9-structure
RON-H52H9-sds
ACRO Quality

Part of Bioactivity data

RON-H52H9-MALS-HPLC
RON MALS images

The purity of Human RON, His Tag (Cat. No. RON-H52H9) is more than 90% and the molecular weight of this protein is around 60-80 kDa verified by SEC-MALS.

Synonym Name

CD136 antigen,CD136,CDw136c-met-related tyrosine kinase,EC 2.7.10,EC 2.7.10.1,macrophage stimulating 1 receptor (c-met-related tyrosine kinase),MSP R,MSP receptor,MSPR,MST1R,p185-Ron,Protein-tyrosine kinase 8,PTK8 protein tyrosine kinase 8,PTK8,Ron,RONmac

Background

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Crizotinib PF-1066; PF-2341066; PF-02341066; PF-002341066 Approved Pfizer Inc 赛可瑞, Xalkori United States Carcinoma, Non-Small-Cell Lung Pf Prism Cv 2011-08-26 Urethral Neoplasms; Neoplasm Metastasis; Adenocarcinoma; Neurilemmoma; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Granuloma, Plasma Cell; Endometrial Neoplasms; Lymphoma, Large-Cell, Anaplastic; Lymphoma; Ureteral Neoplasms; Solid tumours; Lymphoma, Primary Cutaneous Anaplastic Large Cell; Neuroblastoma; Urinary Bladder Neoplasms; Myofibroma; Uveal melanoma; Multiple Myeloma; Neurofibromatosis 2; Neoplasms; Renal Insufficiency; Hematologic Neoplasms Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ningetinib Tosylate CT-053-PTSA; CT-053 Phase 2 Clinical Hec Pharm Co Ltd Solid tumours; Intestinal Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Merestinib 5OGS5K699E; LY-2801653 Phase 2 Clinical Eli Lilly And Company Biliary Tract Neoplasms; Solid tumours; Skin Melanoma; Bone metastases; Pancreatic Neoplasms; Neoplasms; Microsatellite instability-high cancer; Breast Neoplasms; Cholangiocarcinoma; Lymphoma, Mantle-Cell; Colorectal Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Gallbladder Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung Details
Do-2 Do-2 Phase 1 Clinical DeuterOncology NV Lung Neoplasms Details

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