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Your Position: Home > Midkine

Midkine

Brief Information

Name:Midkine
Target Synonym:Midkine,Midgestation and kidney protein,Neurite outgrowth-promoting factor 2,Neurite outgrowth-promoting protein,Amphiregulin-associated protein,NEGF2,ARAP,FLJ27379,Neurite Growth-Promoting Factor 2,Retinoic Acid Inducible Factor,MK1,MDK,MK
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Clinical

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Cat. No. Species Product Description Structure Purity Feature
MIE-H5117 Human Human Midkine / Mdk Protein, premium grade
MIE-H5117-structure
MIE-H5117-sds
MIE-H5117-hplc
MIE-M82Q8 Mouse Biotinylated Mouse Midkine / Mdk Protein, His,Avitag™
MIE-M82Q8-structure
ACRO Quality

Part of Bioactivity data

MIE-H5117-SPR
Midkine SPR

Human Midkine Protein, premium grade (Cat. No. MIE-H5117) immobilized on CM5 Chip can bind Human Glypican 2, His Tag (Cat. No. GP2-H52H3) with an affinity constant of 44.9 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
MIE-H5117-ELISA
Midkine ELISA

Immobilized Human Midkine Protein, premium grade (Cat. No. MIE-H5117) at 2 μg/mL (100 μL/well) can bind Human Glypican 2, His Tag (Cat. No. GP2-H52H3) with a linear range of 1-63 ng/mL (QC tested).

Protocol

Synonym Name

MDK,MEK,Midkine,MK1,MKARAP,NEGF2,Retinoic acid-induced differentiation factor

Background

Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors.Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups.Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration. Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CMK-103 CMK-103 Clinical Cellmid Myocardial Infarction Details

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