Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > SIGIRR

SIGIRR

Brief Information

Name:Toll like receptor 4
Target Synonym:EC:3.2.2.6,TLR4,Toll Like Receptor 4,Toll-Like Receptor 4,HToll,Homolog Of Drosophila Toll,CD284 Antigen,ARMD10,CD284,TLR-4,TOLL,Toll Like Receptor 4 Protein
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:14
Lastest Research Phase:Approved

Product ListCompare or Buy

By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
SIR-H5255 Human Human SIGIRR Protein, Fc Tag (MALS verified)
SIR-H5255-structure
SIR-H5255-sds
ACRO Quality

Part of Bioactivity data

SIR-H5255-ELISA
Human SIGIRR, Fc Tag (Cat. No. ) MALS images

The purity of Human SIGIRR, Fc Tag (Cat. No. SIR-H5255) is more than 95% and the molecular weight of this protein is around 85-120 kDa verified by SEC-MALS.

  • Background
    Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

Single Ig IL-1-related receptor,Single Ig IL-1R-related molecule,Single immunoglobulin domain-containing IL1R-related protein,Toll/interleukin-1 receptor 8,TIR8

Background

Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Ibudilast AV-411; KC-404; MN-166 Approved Ketas, Pinatos, Eyevinal Japan Asthma; Multiple Sclerosis; Neuralgia Kyorin Pharmaceutical Co Ltd Substance-Related Disorders; HIV Infections; Opioid-Related Disorders; Headache Disorders, Secondary; Diabetic Neuropathies; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Pneumonia, Viral; Alcoholism; Asthma; Neuralgia; Amyotrophic Lateral Sclerosis Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Mosedipimod EC-18 Phase 2 Clinical Enzychem Lifesciences Co Neutropenia; Coronavirus Disease 2019 (COVID-19); Stomatitis; Febrile Neutropenia; Dermatitis, Atopic Details
Paridiprubart EB-07; EB-05; NI-0101 Phase 2 Clinical Novimmune Sa Coronavirus Disease 2019 (COVID-19); Pulmonary Fibrosis; Respiratory Distress Syndrome, Adult Details
PEPA-10 PEPA-10 Phase 2 Clinical Immunovo BV Neoplasms Details
eNamptcumab ALT-100 Phase 2 Clinical Aqualung Therapeutics Corp Ventilator-Induced Lung Injury; Respiratory Distress Syndrome, Adult; Pulmonary Fibrosis; Prostatic Neoplasms; Pulmonary Arterial Hypertension; Chorioamnionitis Details
Glycopyranosyl lipid adjuvant (Immune Design) GLA; G100; GLA-SE; ID-G100; G-100 Phase 2 Clinical Immune Design HIV Infections; Skin Melanoma; Malaria, Falciparum; Tuberculosis, Pulmonary; Sarcoma; Hookworm Infections; Leishmaniasis; Schistosomiasis Details
Glycopyranosyl lipid adjuvant (Revelation Biosciences) PHAD (Revelation Biosciences); REVTx 99; REVTx-99a; REVTx-99b; REVTx-100 (Revelation Biosciences); REVTx-200 (Revelation Biosciences); REVTx-300 (Revelation Biosciences); GLA (Revelation Biosciences) Phase 2 Clinical Revelation Biosciences Inc Cross Infection; Influenza A virus infections; Acute Kidney Injury; Surgical Wound Infection; Renal Insufficiency, Chronic; Myocarditis Details
TARA-002(Protara Therapeutics) TARA-002 Phase 2 Clinical Protara Therapeutics Inc Urinary Bladder Neoplasms; Lymphatic Abnormalities Details
ApTOLL Phase 2 Clinical aptaTargets SL Stroke; Ischemic Stroke Details
Temelimab GNN-001; GENHP-01; GNbAC-1 Phase 2 Clinical Geneuro Sa Multiple Sclerosis, Relapsing-Remitting; Diabetes Mellitus, Type 1; Multiple Sclerosis; Post-Acute COVID-19 Syndrome Details
GSK-1795091 1795091; GSK-1795091; CRX-601 Phase 1 Clinical Glaxosmithkline Plc Neoplasms Details
PET-lipid A Phase 1 Clinical Cascadian Therapeutics Inc Vaccination Details
SAR-439794 SAR-439794 Phase 1 Clinical Sanofi Food Hypersensitivity Details
INI-2004 INI-2004 Phase 1 Clinical Inimmune Corp Respiratory Tract Infections; Neoplasms; Food Hypersensitivity; Rhinitis, Allergic Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message