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Your Position: Home > CXCL10

CXCL10

Brief Information

Name:C-X-C motif chemokine ligand 10
Target Synonym:Protein 10 From Interferon (Gamma)-Induced Cell Line,CXCL10,INP10,SCYB10,C-X-C motif chemokine 10,10 kDa interferon gamma-induced protein,IP-10,C-X-C Motif Chemokine Ligand 10,Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10,Chemokine (C-X-C Motif) Ligand 10,Small-Inducible Cytokine B10,Chemokine CXCL10,Interferon-Inducible Cytokine IP-10,Gamma IP10,Gamma-IP10,GIP-10,IFI10,Crg-2,Mob-1,C7
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CX0-H5113 Human Human CXCL10 Protein, Tag Free
CX0-H5113-structure
CX0-H5113-sds
CEA-C028 Human ClinMax™ Human CXCL10/IP-10 ELISA Kit
ACRO Quality

Part of Bioactivity data

CX0-H5113-MALS-HPLC
CXCL10 ELISA

Immobilized Human CXCL10 Protein, Tag Free (Cat. No. CX0-H5113) at 5 μg/mL (100 μL/well) can bind Human CXCR3 Protein, Flag,His Tag (Cat. No. CX3-H52D5) with a linear range of 0.039-10 μg/mL (QC tested).

Protocol

Synonym Name

C-X-C motif chemokine 10,10 kDa interferon gamma-induced protein,Gamma-IP10,IP-10,Small-inducible cytokine B10,CXCL10(1-73),CXCL10,INP10, SCYB10

Background

C-X-C Motif Chemokine Ligand 10 (CXCL10) is a pro-inflammatory chemokine secreted by a wide spectrum of cells. It is involved in multiple mechanisms and reported to have pleiotropic effects, including immune cell migration and attraction to inflammation sites, angiogenesis, and cancer cell growth. CXCL10 is produced by pancreatic islet cells upon inflammatory stress and is specifically recognized by C-X-C Motif Chemokine Receptor 3 (CXCR3) which is expressed by activated T-lymphocytes and other immune cells.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
JT-02 (JYANT Technologies) JT-02 Phase 2 Clinical Jyant Technologies Inflammatory Bowel Diseases Details
NG-641 EnAd-FAP-BiTE; EnAd-FAP-Tac; NG-641; NG-aFAP Phase 1 Clinical Akamis Bio Ltd, University Of Oxford Squamous Cell Carcinoma of Head and Neck; Neoplasms, Glandular and Epithelial; Neoplasm Metastasis Details

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