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Your Position: Home > CCL24

CCL24

Brief Information

Name:Chemokine (C-C Motif) Ligand 24
Target Synonym:Small Inducible Cytokine Subfamily A (Cys-Cys), Member 24,Chemokine (C-C Motif) Ligand 24,Small-Inducible Cytokine A24,MPIF-2,Ckb-6,Chemokine CCL24,MPIF2,SCYA24,Eotaxin-2,CK-beta-6,Myeloid progenitor inhibitory factor 2,C-C motif chemokine 24,CCL24,C-C Motif Chemokine Ligand 24,Eosinophil Chemotactic Protein 2
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CC4-H52H1 Human Human CCL24/Eotaxin-2 Protein, His Tag (HPLC verified)
CC4-H52H1-structure
CC4-H52H1-sds
CC4-H52H1-hplc
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Synonym Name

C-C motif chemokine 24,CK-beta-6,Eosinophil chemotactic protein 2,Myeloid progenitor inhibitory factor 2,Small-inducible cytokine A24,Eotaxin-2,MPIF-2,SCYA24,MPIF2

Background

C-C motif chemokine ligand 24 (CCL24), also known as eotaxin2, belongs to CC chemokines like MCP-1, and it mainly chemoattracts eosinophils. CCL24 can promote the separation of eosinophils from endothelial cells and then combine with its sole ligand to promote eosinophils to enter the tissue. CCL24 was not originally found in eosinophils but was first isolated from monocytes. Latest, it was found that the expression of CCL24 in the bronchial epithelial cells of asthma patients increased. CCL24 promotes immune cell trafficking and activation as well as profibrotic activities through the CCR3 receptor (C-C chemokine receptor type 3). Both CCL24 and CCR3 is involved in lung and skin inflammation and fibrosis.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
CM-101 (ChemomAb) CM-101 Phase 2 Clinical Chemomab Therapeutics Ltd Metabolic Dysfunction-Associated Steatotic Liver Disease; Scleroderma, Systemic; Cholangitis, Sclerosing Details

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