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Human M-CSF Protein, His Tag (Cat. No. MCF-H5247) captured on CM5 Chip via anti-His antibody can bind Human M-CSF R Protein, Fc Tag (Cat. No. CSR-H5258) with an affinity constant of 1.9 nM as determined in SPR assay (Biacore T200) (Routinely tested).
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Regorafenib | DAST; BAY-73-4506 | Approved | Bayer AG | Stivarga, Resihance | United States | Colorectal Neoplasms | Bayer Healthcare Pharmaceuticals Inc | 2012-09-27 | Leukemia, Myeloid, Acute; Sarcoma, Ewing; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Bone Neoplasms; Peritoneal Neoplasms; Bile Duct Neoplasms; Esophageal adenocarcinoma; Lung Neoplasms; Thyroid Neoplasms; Fallopian Tube Neoplasms; Osteosarcoma; Thymoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Neoplasm Metastasis; Adenocarcinoma; Somatostatinoma; Gastrointestinal Neoplasms; Melanoma; Meningioma; Neoplasms; Solid tumours; Liver Neoplasms; Stomach Neoplasms; Esophageal Neoplasms; Insulinoma; Carcinoma, Islet Cell; Hemangiosarcoma; Rectal Neoplasms; Carcinoma, Renal Cell; Ovarian Neoplasms; Colonic Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic Neoplasms; Carcinoma, Transitional Cell; Adenoma; Glucagonoma; Carcinoma, Adenoid Cystic; Gastrinoma; Sarcoma | Details |
| Nintedanib Esylate | BIBF-1120 | Approved | C.H. Boehringer Sohn Ag & Co. Kg | Ofev, Vargatef | United States | Idiopathic Pulmonary Fibrosis | Boehringer Ingelheim Gmbh | 2014-10-15 | Astrocytoma; Sarcoma; Prostatic Neoplasms; Breast Neoplasms; systemic sclerosis-associated interstitial lung disease; Adenocarcinoma, Clear Cell; Peritoneal Neoplasms; Colorectal Neoplasms; Silicosis; Genital Neoplasms, Female; Hepatic Insufficiency; Oligodendroglioma; Gliosarcoma; Uterine Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Squamous Cell; Leukemia, Myeloid, Acute; Appendiceal Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Glioblastoma; Solid tumours; Telangiectasia, Hereditary Hemorrhagic; Carcinoma, Renal Cell; Endometrial Stromal Tumors; Carcinoid Tumor; Radiation Pneumonitis; Esophageal Neoplasms; Rejection of lung transplantation; Idiopathic Pulmonary Fibrosis; Neoplasms; Ovarian Neoplasms; Small Cell Lung Carcinoma; Colonic Neoplasms; Scleroderma, Systemic; Lung Diseases, Interstitial; Pulmonary Fibrosis; Mesothelioma; Multiple Myeloma; Asbestosis; Neuroendocrine Tumors | Details |
| pacritinib citrate | SB-1518; ONX-0803 | Approved | S*BIO Pte Ltd, Concert | VONJO | United States | Primary Myelofibrosis | Sobi | 2022-02-28 | Lymphoproliferative Disorders; Sarcoma, Kaposi; Leukemia, Lymphocytic, Chronic, B-Cell; Thrombocythemia, Essential; Carcinoma, Non-Small-Cell Lung; Inflammation; Lymphoma; Lymphoma, T-Cell, Cutaneous; Lymphoma, Non-Hodgkin; Waldenstrom Macroglobulinemia; Lymphoma, T-Cell; Leukemia, Myeloid, Acute; Thrombocytopenia; Leukemia, Myelomonocytic, Juvenile; Hepatic Insufficiency; Castleman Disease; Leukemia, Myelogenous, Chronic; Colorectal Neoplasms; Primary Myelofibrosis; X-Linked Combined Immunodeficiency Diseases; Lymphoma, Mantle-Cell; Coronavirus Infections; Hodgkin Disease; Graft vs Host Disease; Leukemia, Myelomonocytic, Chronic; Myeloproliferative Disorders; Myelodysplastic Syndromes; Coronavirus Disease 2019 (COVID-19); Polycythemia Vera; Lymphoma, B-Cell; Lymphoma, T-Cell, Peripheral; Leukemia | Details |
| Surufatinib | HMPL-012 | Approved | Hutchison Medipharma Ltd | 苏泰达, SULANDA | Mainland China | Neuroendocrine Tumors | Hutchison Medipharma Ltd | 2020-12-29 | Biliary Tract Neoplasms; Solid tumours; Intestinal Neoplasms; Hematologic Neoplasms; Renal Insufficiency; Neoplasms; Pancreatic neuroendocrine tumors (pNET); Small Cell Lung Carcinoma; Pancreatic Neoplasms; Neuroendocrine Tumors; Sarcoma; Hepatic Insufficiency; Bile Duct Neoplasms; Appendiceal Neoplasms; Thyroid Neoplasms; Carcinoma, Neuroendocrine | Details |
| Sunitinib Malate | PNU-290940AD; PHA-290940AD; SCAI-003; SU-010398; SU-11248; GB-102; PHA-290940; PNU-290940; SU-011248-L-malate salt | Approved | Pfizer Inc | Sutent, 索坦 | United States | Carcinoma, Renal Cell; Gastrointestinal Stromal Tumors | Cppi Cv | 2006-01-26 | Kidney Neoplasms; Skin Melanoma; Teratoma; Liver Neoplasms; Ovarian Neoplasms; Ependymoma; Head and Neck Neoplasms; Lymphoma, T-Cell, Peripheral; Solid tumours; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myelogenous, Chronic; Leiomyosarcoma; Lymphoma, B-Cell; HIV Infections; Fibrosarcoma; Intestinal Neoplasms; Fibromatosis, Aggressive; Leukemia; Lymphoma, B-Cell, Marginal Zone; Carcinoma, Renal Cell; Pheochromocytoma; Stomach Neoplasms; Abdominal Neoplasms; Pelvic Neoplasms; Polycythemia Vera; Thoracic Neoplasms; Esophageal Neoplasms; Carcinoma, Islet Cell; Carcinoma; Histiocytoma, Malignant Fibrous; Hemangioblastoma; Squamous Cell Carcinoma of Head and Neck; Leukemia, Hairy Cell; Nose Neoplasms; Hypopharyngeal Neoplasms; Carcinoma, Ovarian Epithelial; Pancreatic neuroendocrine tumors (pNET); Plasmacytoma; Neoplasms; Pancreatic Neoplasms; Glioblastoma; Lymphoma, Large B-Cell, Diffuse; Lymphomatoid Granulomatosis; Lymphoma, Large-Cell, Immunoblastic; Myelodysplastic Syndromes; Carcinoma, Transitional Cell | Details |
| Axatilimab | SNDX-6352; UCB-6352; INCA-34176; INCA034176; INCA-034176 | Approved | Ucb | NIKTIMVO | United States | Graft vs Host Disease | Incyte Corp | 2024-08-14 | Myeloproliferative Disorders; Myelodysplastic-Myeloproliferative Diseases; Neoplasm Metastasis; Coronavirus Infections; Cholangiocarcinoma; Breast Neoplasms; Respiratory Distress Syndrome, Adult; Neoplasms; Leukemia, Myelomonocytic, Chronic; Solid tumours; Hodgkin Disease; Idiopathic Pulmonary Fibrosis; Triple Negative Breast Neoplasms; Graft vs Host Disease; Leukemia, Myelogenous, Chronic; Bone Marrow Neoplasms; Cytokine Release Syndrome | Details |
| Pexidartinib | PLX-3397 | Approved | Daiichi Sankyo Co Ltd | Turalio | United States | Giant Cell Tumor of Tendon Sheath | Daiichi Sankyo Inc | 2019-08-02 | Prostatic Neoplasms; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Melanoma; Metastatic breast cancer; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Neurofibroma, Plexiform; Neurofibrosarcoma; Giant Cell Tumors; Sarcoma; Giant Cell Tumor of Tendon Sheath; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pancreatic Neoplasms; Neoplasms; Arthritis, Rheumatoid; Hodgkin Disease; Glioblastoma; Squamous Cell Carcinoma of Head and Neck; Synovitis, Pigmented Villonodular; Leukemia, Promyelocytic, Acute; Ovarian Neoplasms; Solid tumours | Details |
| Mirimostim | P-100; CSF-HU | Approved | Jcr Pharmaceuticals Co Ltd | Costilate, Leukoprol | Japan | Neutropenia | Jcr Pharmaceuticals Co Ltd | 1991-01-01 | Neutropenia | Details |
| Pazopanib Hydrochloride | GSK-786034; GW-786034B; SB-786034; GW-786034 | Approved | Glaxosmithkline Plc, Novartis Pharma Ag | 维全特, Armala, Votrient, Patorma | United States | Carcinoma, Renal Cell; Sarcoma | Novartis Pharma Ag | 2009-10-19 | Osteosarcoma; Germinoma; Fallopian Tube Neoplasms; Leukemia, Myeloid, Acute; Colorectal Neoplasms; Uterine Cervical Diseases; Genital Neoplasms, Female; Gliosarcoma; Gastrointestinal Stromal Tumors; Peritoneal Neoplasms; Chondrosarcoma, Extraskeletal Myxoid; Lung Neoplasms; Nasopharyngeal Carcinoma; Medullary thyroid cancer (MTC); Brain Neoplasms; Urethral Neoplasms; Psoriasis; Gastrinoma; Neuroblastoma; Prostatic Neoplasms; Breast Neoplasms; Neoplasms, Germ Cell and Embryonal; von Hippel-Lindau Disease; Thyroid Cancer, Papillary; Neoplasm Metastasis; Breast Neoplasms, Male; Uterine Cervical Neoplasms; Endodermal Sinus Tumor; Paraganglioma; Melanoma; Macular Degeneration; Carcinoma, Hepatocellular; Sarcoma; Gastrointestinal Neoplasms; Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Choriocarcinoma; Uterine Neoplasms; Lymphoma; Carcinoma, Neuroendocrine; Glioma; Carcinoma, Embryonal; Skin Melanoma; Neoplasms; Herpes Genitalis; Hemangiosarcoma; Squamous Cell Carcinoma of Head and Neck; Insulinoma; Pheochromo | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Simmitinib hydrochloride | SOMCL-15-290 | Phase 3 Clinical | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Solid tumours; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Breast Neoplasms; Esophageal Squamous Cell Carcinoma | Details |
| Seralutinib | GB-002; PK-10571 | Phase 3 Clinical | Gilead Sciences Inc | Pulmonary Arterial Hypertension | Details |
| Chiauranib | CS-2164; CS2164 | Phase 3 Clinical | Shenzhen Chipscreen Biosciences Co Ltd | Ovarian Neoplasms; Solid tumours; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Neoplasms; Sarcoma; Lymphoma, Non-Hodgkin; Carcinoma, Pancreatic Ductal; Carcinoma, Hepatocellular | Details |
| Pimicotinib | ABSK-021 | Phase 3 Clinical | ABbisko Therapeutics Co Ltd | Giant Cell Tumor of Tendon Sheath; Solid tumours; Synovitis, Pigmented Villonodular; Neoplasms; Graft vs Host Disease; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Sarcoma; Lung Neoplasms; Amyotrophic Lateral Sclerosis | Details |
| Emactuzumab | RG-7155; 6FY6EI1X8R; RO-5509554 | Phase 3 Clinical | F. Hoffmann-La Roche Ltd | Head and Neck Neoplasms; Solid tumours; Carcinoma; Neoplasms; Prostatic Neoplasms; Testicular Neoplasms; Carcinoma, Squamous Cell; Lymphoma, Non-Hodgkin | Details |
| Recombinant human GM-CSF oncolytic herpes simplex virus type 2 (OH2) | BS-001; BS001; oHSV-2; OH-2; OH2; OH2 injection; oHSV2hGM-CSF | Phase 3 Clinical | Wuhan Binhui Biotechnology Co Ltd | Central Nervous System Neoplasms; Melanoma; Lymphoma; Lung Neoplasms; Colorectal Neoplasms; Bile Duct Neoplasms; Sarcoma; Breast Neoplasms; Digestive System Neoplasms; Liver Neoplasms; Liver Diseases; Urinary Bladder Neoplasms; Neoplasms; Pancreatic Neoplasms; Glioblastoma; Esophageal Neoplasms; Solid tumours; Head and Neck Neoplasms | Details |
| Tinengotinib | TT-00420; TT 00420; TT00420 | Phase 3 Clinical | TransThera Sciences (Nanjing) Inc | Biliary Tract Neoplasms; Solid tumours; Carcinoma, Renal Cell; Stomach Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Cholangiocarcinoma; Sarcoma; Prostatic Neoplasms; Gallbladder Neoplasms; Thyroid Neoplasms | Details |
| LY-3022855 | IMC-CS4; LY-3022855 | Phase 2 Clinical | Eli Lilly And Company | Solid tumours; Neoplasms; Pancreatic Neoplasms; Melanoma; Neoplasm Metastasis | Details |
| Cabiralizumab | FPA-008; ONO-4687; BMS-986227 | Phase 2 Clinical | Five Prime Therapeutics Inc | Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Giant Cell Tumor of Tendon Sheath; Lymphoma, T-Cell, Peripheral; Carcinoma, Renal Cell; Synovitis, Pigmented Villonodular; Neoplasms; Triple Negative Breast Neoplasms; Arthritis, Rheumatoid; Pancreatic Neoplasms; Glioma; Carcinoma, Non-Small-Cell Lung | Details |
| Narazaciclib | ON-123300; HX-301 | Phase 2 Clinical | Temple University | Solid tumours; Glioblastoma; Multiple Myeloma; Breast Neoplasms; Glioma; Endometrial Neoplasms | Details |
| Derazantinib | ARQ-087.2HCl; AQ-14741087; ARQ-087; BAL-087 | Phase 2 Clinical | Arqule Inc | Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Cholangiocarcinoma; Urogenital Neoplasms; Carcinoma, Hepatocellular | Details |
| HH185 | 3D-185; 3-D185; HH-185; 3D185 | Phase 2 Clinical | ShangHai HaiHe Biopharma Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, Shanghai Medicilon Inc | Solid tumours; Cholangiocarcinoma | Details |
| C-019199 | C019199 | Phase 2 Clinical | Fujian Haixi Pharmaceuticals Co Ltd | Giant Cell Tumor of Tendon Sheath; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Pancreatic Neoplasms; Triple Negative Breast Neoplasms; Osteosarcoma; Breast Neoplasms; Colorectal Neoplasms; Esophageal Squamous Cell Carcinoma; Melanoma | Details |
| Elzovantinib | TPX-0022 | Phase 2 Clinical | Turning Point Therapeutics Inc | Solid tumours; Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| AMB-066 | AMB-066 | Phase 2 Clinical | The University Of Texas MD Anderson Cancer Center, AmMax Bio Inc | Colorectal Neoplasms | Details |
| BS-008 | BS001/BS006; BS001+BS006 | Phase 2 Clinical | Wuhan Binhui Biotechnology Co Ltd | Solid tumours; Sarcoma; Colorectal Neoplasms | Details |
| Enrupatinib | EI-1071; FB-1071 | Phase 2 Clinical | Elixiron Immunotherapeutics Inc | Giant Cell Tumor of Tendon Sheath; Alzheimer Disease; Nervous System Diseases; Amyotrophic Lateral Sclerosis | Details |
| [11C]CPPC | Phase 2 Clinical | Johns Hopkins University | Post-Acute COVID-19 Syndrome; Amyotrophic Lateral Sclerosis | Details | |
| AMB-051 | AMB 053; AMB-055; AMG-820; AMB-051; AMB-05X | Phase 2 Clinical | Amgen Inc | Giant Cell Tumor of Tendon Sheath; Solid tumours; Synovitis, Pigmented Villonodular; Idiopathic Pulmonary Fibrosis; Neoplasms; Pancreatic Neoplasms; Testicular Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
| Adrixetinib | Q-702 | Phase 2 Clinical | Vichem Chemie, Max Planck Institute of Biochemistry, Lead Discovery Center GmbH | Lymphoma, Follicular; Central Nervous System Lymphoma; Uterine Cervical Neoplasms; Carcinoma, Hepatocellular; Neoplasm Metastasis; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous; Waldenstrom Macroglobulinemia; Primary Myelofibrosis; Histiocytic Sarcoma; Erdheim-Chester Disease; Hematologic Neoplasms; Histiocytosis, Langerhans-Cell; Histiocytosis, Sinus; Neoplasms; Graft vs Host Disease; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Stomach Neoplasms; Esophageal Neoplasms; Leukemia, Lymphoid; Solid tumours; Lymphoma, T-Cell, Peripheral | Details |
| SYHA-1813 | SYHA1813 | Phase 2 Clinical | Shanghai Runshi Pharmaceutical Technology Co Ltd, Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Solid tumours; Giant Cell Tumor of Tendon Sheath; Liver Neoplasms; Carcinoma, Renal Cell; Stomach Neoplasms; Small Cell Lung Carcinoma; Colorectal Neoplasms; Gliosarcoma; Lung Neoplasms; Brain metastases; Glioma; Thyroid Neoplasms; Meningioma | Details |
| PMI-04 | Phase 1 Clinical | Precision Molecular Inc | Nerve Degeneration | Details | |
| APL-102 | APL-102; CBT-102 | Phase 1 Clinical | Apollomics Inc | Solid tumours | Details |
| Edicotinib | PRV-6527; JNJ-244; JNJ-40346527-AAC-G-002; JNJ-40346527; JNJ-527 | Phase 1 Clinical | Johnson & Johnson | Hodgkin Disease; Arthritis, Rheumatoid; Prostatic Neoplasms; Alzheimer Disease; Cognitive Dysfunction; Leukemia, Myeloid, Acute; Crohn Disease | Details |
| Pamufetinib | TAS-115 | Phase 1 Clinical | Taiho Pharmaceutical Co Ltd, Otsuka Pharmaceutical Co Ltd | Neoplasms | Details |
| JDB-383 | JDB-383 | Phase 1 Clinical | Shanghai Jiabao Yaoyin Pharmaceutical Technology Co Ltd | Giant Cell Tumor of Tendon Sheath | Details |
| HMPL-653 | HMPL-653 | Phase 1 Clinical | Hutchison Medipharma Ltd | Solid tumours; Giant Cell Tumor of Tendon Sheath; Testicular Neoplasms | Details |
| MNKD-201 | MNKD-201; MKND-201 | Phase 1 Clinical | MannKind Corp | Idiopathic Pulmonary Fibrosis | Details |
| Inhaled Nintedanib – dry powder (Avalyn Pharma) | AP02; AP 02 DP; AP-02; AP02-DP | Phase 1 Clinical | Avalyn Pharma Inc | Idiopathic Pulmonary Fibrosis; Respiratory Tract Diseases; Lung Diseases, Interstitial; Pulmonary Fibrosis | Details |
| ETH-155036 | ETH-155036; ETH155036 | Phase 1 Clinical | Shengke Pharmaceutical (Jiangsu) Co Ltd | Myelodysplastic Syndromes; Leukemia, Myeloid, Acute | Details |
| Caflanone | FBL-03G | Phase 1 Clinical | Flavocure Biotech Inc | Pancreatic Neoplasms | Details |
| SYHA-1817 | SYHA-1817 | Phase 1 Clinical | CSPC Pharmaceutical Group Ltd | Biliary Tract Neoplasms; Stomach Neoplasms; Carcinoma, Squamous Cell | Details |
| TT-00420/Atezolizumab | Phase 1 Clinical | TransThera Sciences (Nanjing) Inc | Gastrointestinal Neoplasms | Details | |
| BC-006 | BC-006; BC006; ADG125; ADG-125 | Phase 1 Clinical | Adagene Inc | Giant Cell Tumor of Tendon Sheath; Solid tumours | Details |
| AGX-0073 | AGX-0073 | Phase 1 Clinical | Shanghai Aojian Biological Technology Co Ltd | Solid tumours | Details |
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