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| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Fingolimod Hydrochloride | FTY-720A; TDI-132; FTY-720 | Approved | Novartis Pharma Ag | Gilenia, Imusera, 捷灵亚, Gilenya | United States | Multiple Sclerosis | Novartis Pharma Ag | 2010-09-21 | Multiple Sclerosis; Amyotrophic Lateral Sclerosis; Carcinoma, Non-Small-Cell Lung; Hemorrhagic Stroke; Uveitis; Hypesthesia; Brain Edema; Intracranial Hemorrhage, Hypertensive; Asthma; Breast Neoplasms; Optic Neuritis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Small Cell Lung Carcinoma; Cerebral Hemorrhage, Traumatic; Rett Syndrome; Schizophrenia; Renal Insufficiency; Cerebral Hemorrhage; Pain; Peripheral Nervous System Diseases; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Rejection of renal transplantation | Details |
| Ozanimod hydrochloride | CYM-5442; RPC-1063; 盐酸奥扎莫德 | Approved | The Scripps Research Institute Inc | Zeposia, 热珀西亚 | United States | Multiple Sclerosis | Bristol-Myers Squibb Company | 2020-03-25 | Multiple Sclerosis, Relapsing-Remitting; Digestive System Diseases; Gram-Negative Bacterial Infections; Coronavirus Disease 2019 (COVID-19); Multiple Sclerosis; Liver Diseases; Colitis, Ulcerative; Crohn Disease | Details |
| Etrasimod arginine | APD-334; MXE5EMA09L; APD-334 L-Arginine; PF-07915503 | Approved | Arena Pharmaceuticals Inc | VELSIPITY | United States | Colitis, Ulcerative | Pfizer Inc | 2023-10-12 | Pyoderma Gangrenosum; Inflammatory Bowel Diseases; Alopecia Areata; Eosinophilic Esophagitis; Anemia, Aplastic; Cholangitis, Sclerosing; Colitis, Ulcerative; Crohn Disease; Eczema; Dermatitis, Atopic | Details |
| Fingolimod lauryl sulfate | Approved | Handa Neuroscience LLC | Tascenso ODT | United States | Multiple Sclerosis, Relapsing-Remitting | Cycle Pharmaceuticals Ltd | 2021-12-23 | Multiple Sclerosis, Relapsing-Remitting | Details | |
| Siponimod | NVP-BAF312-AEA; BAF-312; NVP-BAF312-NX | Approved | Novartis Pharma Ag | Mayzent | United States | Multiple Sclerosis | Novartis Pharma Ag | 2019-03-26 | Polymyositis; Multiple Sclerosis, Relapsing-Remitting; Dermatomyositis; Cerebral Hemorrhage; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Hepatic Insufficiency; Alzheimer Disease; Cognitive Dysfunction; Hemorrhagic Stroke | Details |
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