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ErbB3

Brief Information

Name:Receptor tyrosine-protein kinase erbB-3
Target Synonym:EC:2.7.10.1,FERLK,EC 2.7.10,Proto-oncogene-like protein c-ErbB-3,HER3,ERBB3,Erb-B2 Receptor Tyrosine Kinase 3,V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3,Tyrosine Kinase-Type Cell Surface Receptor HER3,Human Epidermal Growth Factor Receptor 3,Lethal Congenital Contracture Syndrome 2,Receptor Tyrosine-Protein Kinase ErbB-3,EC 2.7.10.1,P180-ErbB3,P45-SErbB3,P85-SErbB3,MDA-BF-1,C-ErbB-3,C-ErbB3,ErbB3-S,ErbB-3,LCCS2,Receptor, ErbB-3
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:25
Lastest Research Phase:Approved

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Part of Bioactivity data

CHEK-ATP149-Cell-based assay
 ErbB3 FACS

Expression analysis of human ErbB3 on HEK293/Human ErbB3 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human ErbB3 Stable Cell Line or negative control cell using PE-labeled anti-human ErbB3 antibody.

ER3-H82E6-ELISA
 ErbB3 ELISA

Immobilized Biotinylated Human ErbB3, His,Avitag (Cat. No. ER3-H82E6) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human NRG1 Beta 1, Fc Tag, premium grade (Cat. No. NR1-H5268) with a linear range of 0.2-3 ng/mL (QC tested).

ER3-M52H5-MALS-HPLC
ErbB3 MALS images

The purity of Mouse ErbB3, His Tag (Cat. No. ER3-M52H5) is more than 85% and the molecular weight of this protein is around 75-110 kDa verified by SEC-MALS.

Synonym Name

ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3

Background

ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

Clinical and Translational Updates

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