Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > FKBP12

FKBP12

Brief Information

Name:FK506-binding protein 1A
Target Synonym:Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A,FK506-Binding Protein, T-Cell, 12-KD,FK506-Binding Protein 1A (12kD),Protein Kinase C Inhibitor 2,FK506-Binding Protein 12,FK506 Binding Protein12,FK506-Binding Protein 1,FKBP12-Exip3,Calstabin 1,PPIASE,PKC12,PKCI2,Tacrolimus Binding Protein 1A,FKBP12C,FK506 Binding Protein 1A, 12kDa,12 KDa FK506-Binding Protein,Immunophilin FKBP12,12 KDa FKBP,Rotamase,FKBP Prolyl Isomerase 1A,FKBP1,FKBP12,FKBP-12,PPIase FKBP1A,FK506-binding protein 1A,Calstabin-1,FKBP-
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

Product ListCompare or Buy

By Product Status:
By Product Category:
By Species:
By Tag:
By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
FKA-H5122 Human Human FKBP12 / FKBP1A Protein, His Tag
FKA-H5122-structure
FKA-H5122-sds
ACRO Quality

Synonym Name

FKBP1A,FKBP1,Calstabin-1,FKBP12,Rotamase,PKC12,PPIASE

Background

Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Tacrolimus Hydrate LCP-Tacro; FR-900506; L-679934; FK-506MR; FK-506E; FK-506; MR-4; RTU-007 Approved Astellas Pharma Inc Protopy, Graceptor (as hydrate), Protopic, Prograf (as hydrate), Hecoria (as hydrate), Hexal, Envarsus XR, Talymus, 普乐可复, Advagraf, Envarsus, Modigraf, Astagraf XL, TacroBell United States Rejection in heart transplantation; Rejection of liver transplantation; Rejection of renal transplantation Astellas Pharma Us Inc 1994-04-08 Keratoconjunctivitis; Dry Eye Syndromes; Conjunctivitis; Psoriasis; Pulmonary Arterial Hypertension; Amputation, Traumatic; Burns; Asthma; Surgical Wound Infection; Colitis, Ulcerative; Rejection in heart transplantation; Infertility, Female; Lupus Nephritis; Hamman-Rich Syndrome; Nephrotic Syndrome; Renal Insufficiency, Chronic; Wounds and Injuries; Vitiligo; Dermatitis, Atopic; Peripheral Nerve Injuries; Ocular inflammation; Edema; Encephalitis; Crohn Disease; Glomerulonephritis, IGA; Rejection of renal transplantation; Reperfusion Injury; Myasthenia Gravis; Medication Adherence; Keratoconjunctivitis Sicca; Genital Diseases, Male; Bone marrow transplant rejection; Liver Failure; Rejection of lung transplantation; Rejection of liver transplantation; Renal Insufficiency; Polymyositis; Primary Graft Dysfunction; Rejection of pancreatic transplantation; Keratoplasty rejection; Dermatomyositis; Kidney Diseases; Lupus Erythematosus, Cutaneous; Graft vs Host Disease; Arthritis, Rheumatoid; Lung Diseases, Intersti Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
MAM-1003-1 MAM-1003-1 Phase 2 Clinical Marinomed Biotech AG Rhinitis, Allergic; Conjunctivitis, Allergic Details
Plerixafor/Tacrolimus Hydrate AMD3100+FK506; MRG-001(MedRegen) Phase 2 Clinical MedRegen LLC Motor Neuron Disease; Cytokine Release Syndrome; Hepatitis, Alcoholic; Respiratory Tract Diseases; Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult; Abdominal Injuries; Wounds and Injuries; Respiratory Insufficiency; Amyotrophic Lateral Sclerosis Details
Rimiducid AP-1903 Phase 2 Clinical Ariad Pharmaceuticals Inc, Bellicum Pharmaceuticals Inc Lymphoma, Non-Hodgkin; Blastic Plasmacytoid Dendritic Cell Neoplasm; Anemia, Aplastic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Osteopetrosis; Metabolic Diseases; Osteosarcoma; Sarcoma; Neuroblastoma; Prostatic Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Leukemia, Myeloid, Acute; Cytopenia; Lymphoma; Lymphohistiocytosis, Hemophagocytic; Congenital Bone Marrow Failure Syndromes; Melanoma; Leukemia, Biphenotypic, Acute; Anemia, Sickle Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Thalassemia; Hematologic Neoplasms; Primary Immunodeficiency Diseases; Solid tumours; Neoplasm, Residual; Bone Marrow Neoplasms; Leukemia; Leukemia, Myelogenous, Chronic; Lymphatic Diseases; Immunoproliferative Disorders; Leukemia, Lymphoid; Lymphoma, B-Cell; Anemia, Diamond-Blackfan; Myeloproliferative Disorders; Myelodysplastic Syndromes; Graft vs Host Disease; Hemoglobinopathies; Leukemia, Myelomonocytic, Chronic; Fanconi Anemia; Uveal melanoma; Mult Details

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message