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Your Position: Home > Follistatin

Follistatin

Brief Information

Name:Follistatin
Target Synonym:Follistatin,Activin-binding protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
FON-H5256 Human Human Follistatin Protein, Fc Tag
FON-H5256-structure
FON-H5256-sds
FON-H52H4 Human Human Follistatin Protein, His Tag, premium grade
FON-H52H4-structure
FON-H52H4-sds
ACRO Quality

Part of Bioactivity data

FON-H52H4-SPR
Follistatin SPR

Human Follistatin Protein, His Tag, premium grade (Cat. No. FON-H52H4) immobilized on CM5 Chip can bind Human latent GDF-8, His Tag (Cat. No. GD8-H5243) with an affinity constant of 364 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
FON-H5256-ELISA
Follistatin ELISA

Immobilized Human Follistatin Protein, Fc Tag (Cat. No. FON-H5256) at 5 μg/mL (100 μL/well) can bind Biotinylated Human latent GDF-8 Protein, His,Avitag with a linear range of 2-63 ng/mL (QC tested).

Protocol

Synonym Name

Follistatin,FST,FS,FSP

Background

Follistatin is also known as activin-binding protein, FST and FSH-suppressing protein (FSP), and is an secreted autocrine glycoprotein that is expressed in nearly all tissues of higher animals. Its primary function is the binding and bioneutralization of members of the TGF-¦Â superfamily, with a particular focus on activin, a paracrine hormone. Currently there are three reported isoforms, FS-288, FS-300, and FS-315. Two, FS-288 and FS-315, are known to be created by alternative splicing of the primary mRNA transcript. FS-300 (porcine follistatin) is thought to be the product of posttranslational modification via truncation of the C-terminal domain from the primary amino-acid chain. The activin-binding protein follistatin is produced by folliculostellate (FS) cells of the anterior pituitary. FS cells make numerous contacts with the classical endocrine cells of the anterior pituitary including gonadotrophs. In the tissues activin has a strong role in cellular proliferation. In the blood, activin and follistatin are both known to be involved in the inflammatory response following tissue injury or pathogenic incursion. Follistatin is involved in the development of the embryo. It has inhibitory action on bone morphogenic proteins (BMPs); BMPs induce the ectoderm to become epidermal ectoderm. Inhibition of BMPs allows neuroectoderm to arise from ectoderm, a process which eventually forms the neural plate. Other inhibitors involved in this process are noggin and chordin. Follistatin and BMPs are also known to play a role in folliculogenesis within the ovary. A study has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular groups, can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
AAV1-FS344 AAV1-Follistatin; AAV1-FS344 Phase 2 Clinical Nationwide Children'S Hospital Becker muscular dystrophy; Myositis, Inclusion Body; Muscular Dystrophy, Duchenne Details

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