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Your Position: Home > Frizzled-5

Frizzled-5

Brief Information

Name:Frizzled-5
Target Synonym:Frizzled Class Receptor 5,C2orf31,HFZ5,Frizzled 5, Seven Transmembrane Spanning Receptor,Frizzled Family Receptor 5,Fz-5,FzE5,Seven-Transmembrane Receptor Frizzled-5,Chromosome 2 Open Reading Frame 31,Frizzled (Drosophila) Homolog 5,HFz5
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
FZ5-H5259 Human Human Frizzled-5 / FZD5 Protein, Fc Tag
FZ5-H5259-structure
FZ5-H5259-sds
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Part of Bioactivity data

FZ5-H5259-ELISA
Frizzled-5 ELISA

Immobilized Human Frizzled-5, Fc Tag (Cat. No. FZ5-H5259) at 1 μg/mL (100 μL/well) can bind Wnt surrogate Human IgG1(D239E,L241M) | Human Lambda with a linear range of 0.1-8 ng/mL (QC tested).

Protocol

Synonym Name

FZD5,Frizzled-5,C2orf31,,Fz-5,hFz5,FzE5

Background

Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Vantictumab OMP-18R5; anti-Fzd7 Phase 1 Clinical Oncomed Pharmaceuticals Inc, Bayer AG Solid tumours; Pancreatic Neoplasms; Metastatic breast cancer; Carcinoma, Non-Small-Cell Lung Details

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