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Your Position: Home > S100B

S100B

Brief Information

Name:Protein Nef
Target Synonym:nef,Negative factor,3 ORF,Protein Nef,F-protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
S1B-H5143 Human Human S100B Protein, His Tag
S1B-H5143-structure
S1B-H5143-sds
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Synonym Name

S100B,NEF,S100,S100beta

Background

S-100 protein beta chain (S100B),a member of the S-100 family, is also known as S-100 protein subunit beta and S100 calcium-binding protein B, which contains two EF-hand domains. S100B can weakly bind calcium but bind zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Also, S100B can bind to and initiate the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction,S100B may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Fuethermore,S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. S100B may mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
HIV clade B mRNA dendritic cell therapy (Immunomic Therapeutics/Universite Libre de Bruxelles) Phase 1 Clinical Immunomic Therapeutics Inc HIV Infections Details

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