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TIM-3

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Cat. No. Species Product Description Structure Purity Feature
TI3-M82E3 Mouse Biotinylated Mouse TIM-3 / HAVCR2 Protein, His,Avitag™ (HPLC verified)
TI3-M82E3-structure
TI3-M82E3-sds
TI3-M82E3-hplc
TI3-H82F8 Human Biotinylated Human TIM-3 / HAVCR2 Protein, Fc,Avitag™ (MALS verified)
TI3-H82F8-structure
TI3-H82F8-sds
TI3-C52H6 Canine Canine TIM-3 / HAVCR2 Protein, His Tag
TI3-C52H6-structure
TI3-C52H6-sds
TM3-H525b Human Human TIM-3 / HAVCR2 Protein, Mouse IgG2a Fc Tag, low endotoxin
TM3-H525b-structure
TM3-H525b-sds
TI3-C52H4 Cynomolgus Cynomolgus TIM-3 / HAVCR2 Protein, His Tag
TI3-C52H4-structure
TI3-C52H4-sds
TM3-H82E7 Human Biotinylated Human TIM-3 / HAVCR2 Protein, Avitag™,His Tag (MALS verified)
TM3-H82E7-structure
TM3-H82E7-sds
TI3-C525b Cynomolgus Cynomolgus TIM-3 / HAVCR2 Protein, Fc Tag
TI3-C525b-structure
TI3-C525b-sds
TI3-M52H1 Mouse Mouse TIM-3 / HAVCR2 Protein, His Tag
TI3-M52H1-structure
TI3-M52H1-sds
TI3-M5252 Mouse Mouse TIM-3 / HAVCR2 Protein, Fc Tag
TI3-M5252-structure
TI3-M5252-sds
TM3-H5258 Human Human TIM-3 / HAVCR2 (22-200) Protein, Fc Tag (MALS verified)
TM3-H5258-structure
TM3-H5258-sds
TM3-H5229 Human Human TIM-3 / HAVCR2 Protein, His Tag (MALS verified)
TM3-H5229-structure
TM3-H5229-sds
ACRO Quality

Part of Bioactivity data

TM3-H5229-SPR
TIM-3 SPR

Anti-Human TIM-3 MAb (human IgG4) captured on CM5 chip via Anti-Human IgG Fc antibodies surface, can bind Human TIM-3, His Tag (Cat. No. TM3-H5229) with an affinity constant of 9.7 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
TM3-H525b-ELISA
TIM-3 ELISA

Immobilized Human TIM-3 Protein, Mouse IgG2a Fc Tag (Cat. No. TM3-H525b) at 2 μg/mL (100 μL/well) can bind Anti-TIM3 MAb, Human IgG4 with a linear range of 0.2-2 ng/mL (QC tested).

Protocol

Synonym Name

HAVCR2,TIM3,TIMD3,FLJ14428,KIM3

Background

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428,  KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

Clinical and Translational Updates

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