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Your Position: Home > CD44

CD44

Brief Information

Name:CD44 antigen
Target Synonym:Hermes Antigen,Hyaluronate Receptor,Cell Surface Glycoprotein CD44,MC56,PGP-1,CD44,CDW44,GP90 Lymphocyte Homing/Adhesion Receptor,MIC4,LHR,Hematopoietic Cell E- And L-Selectin Ligand,CD44 Antigen (Homing Function And Indian Blood Group System),MDU3,Extracellular Matrix Receptor III,Heparan Sulfate Proteoglycan,HUTCH-I,ECMR-III,Epican,Chondroitin Sulfate Proteoglycan 8,Soluble CD44,MDU2,Pgp1,CSPG8,HCELL,Phagocytic Glycoprotein 1,Indian Blood Group Antigen,IN,Phagocytic Glycoprotein I,CD44 Molecul
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:9
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
HGS-S246 Rabbit Recombinant Monoclonal Anti-CD44 Antibody, Rabbit (5G3)
PG1-H5255 Human Human CD44 Protein, Fc Tag (HPLC-verified)
PG1-H5255-structure
PG1-H5255-sds
PG1-H5255-hplc
CD4-H5226 Human Human CD44 Protein, His Tag
CD4-H5226-structure
CD4-H5226-sds
ACRO Quality

Part of Bioactivity data

CD4-H5226-ELISA
CD44 ELISA

Immobilized Human CD44, His Tag (Cat. No. CD4-H5226) at 5 μg/mL (100 μL/well) can bind Hyaluronan biotin sodium salt with a linear range of 39-156 ng/mL (Routinely tested).

Protocol
PG1-H5255-ELISA
CD44 ELISA

Immobilized Hyaluronic Acid at 100 μg/mL (100 μL/well) can bind Human CD44 Protein, Fc Tag (Cat. No. PG1-H5255) with a linear range of 0.156-2.5 μg/mL (Routinely tested).

Protocol

Synonym Name

CD44,CDW44,CSPG8,ECMR-III,HCELL,HUTCH-I,IN,LHR,MC56,MDU2,MDU3,MIC4,Pgp1,Epican

Background

CD44 antigen is a cell-surface glycoprotein involved in cell¨Ccell interactions, cell adhesion and migration. CD44 is expressed in a large number of mammalian cell types. CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled by its posttranslational modifications. One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Paclitaxel/Hyaluronic acid Phase 3 Clinical Fidia Pharma Carcinoma, Papillary; Urinary Bladder Neoplasms Details
CA-102N CA-102N Phase 2 Clinical Biobud Solid tumours; Colorectal Neoplasms Details
YN-001 YN001; YN-001 Phase 2 Clinical Beijing Inno Medicine Co Ltd Plaque, Atherosclerotic; Atherosclerosis; Coronary Artery Disease; Cerebrovascular Disorders; Cardiovascular Diseases Details
AMT-116(Multitude Therapeutics) AMT-116; AMT-116-ADC Phase 2 Clinical Multitude Therapeutics Inc Solid tumours; Head and Neck Neoplasms; Breast Neoplasms; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Hyaluronic acid/Fluorouracil HA-5FU; HA-5-fluorouracil; Hyaluronic acid-5-fluorouracil complex; Hyaluronan acid-5-fluorouracil complex Phase 2 Clinical Monash University, Alchemia Ltd Colorectal Neoplasms Details
AMC-303 AMC-303; HP-558 Phase 1 Clinical Amcure Gmbh Solid tumours; Esophageal Squamous Cell Carcinoma Details
Clodronic acid/Hyaluronic acid Phase 1 Clinical Abiogen Pharma Spa Osteoarthritis Details
177Lu-AKIR001 177Lu-AKIR001 Phase 1 Clinical Akiram Therapeutics AB Head and Neck Neoplasms; Thyroid Carcinoma, Anaplastic; Neoplasms; Vulvar Neoplasms; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
BGC-0228 BGC-0228 Phase 1 Clinical Brightgene Bio-Medical Technology Co Ltd Solid tumours Details
Hyaluronic acid inhalation (Actelion Pharmaceuticals) ETX-100; CTX-100 Actelion Pharmaceuticals Ltd Details

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