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ID | Components | Size |
EP166-C01 | High-bind Plate | 1plate |
EP166-C02 | Human CD73 | 1μg |
EP166-C03 | AMP | 500μL |
EP166-C04 | AMP-CP(CD73 Inhibitor) | 30μL |
EP166-C05 | 1xDilution Buffer | 50mL |
EP166-C06 | Malachite Green Reagent A | 2mL |
EP166-C07 | Malachite Green Reagent B | 2mL |
The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.
INHIBITION OF CD73: AMP BINDING BY AMP-CP
Serial dilutions of AMP-CP (1:1 serial dilution, from 500μm/L to 0.244140625μm/L) was added into CD73: AMP binding reactions. The assay was performed according to the protocol described below. Background was subtracted from data points prior to log transformation and curve fitting (QC tested).
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English Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
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English Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
---|---|---|---|---|---|
Uliledlimab | TJ-4309; TJ-004309; TJD-5 | Phase 3 Clinical | I-Mab Biopharma Co Ltd | Ovarian Neoplasms; Head and Neck Neoplasms; Solid tumours; Triple Negative Breast Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Neoplasm Metastasis | Details |
Quemliclustat | AB-680 | Phase 3 Clinical | Arcus Biosciences Inc | Biliary Tract Neoplasms; Pancreatic Neoplasms; Hormone-Resistant Prostate Neoplasms; Prostatic Neoplasms, Castration-Resistant; Cholangiocarcinoma; Prostatic Neoplasms; Colorectal Neoplasms; Bile Duct Neoplasms; Carcinoma, Pancreatic Ductal; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung | Details |
Oleclumab | MEDI-9447 | Phase 3 Clinical | Medimmune Llc | Prostatic Neoplasms, Castration-Resistant; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Carcinoma, Pancreatic Ductal; Peritoneal Neoplasms; Colorectal Neoplasms; Prostatic Neoplasms; Osteosarcoma; Urinary Bladder Neoplasms; Solid tumours; Liposarcoma; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Carcinoma; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Hemangiosarcoma; Ovarian Neoplasms | Details |
Dalutrafusp alfa | GS-1423; AGEN-1423 | Phase 2 Clinical | Agenus Inc | Solid tumours; Liver Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal | Details |
BMS-986179 | BMS-986179 | Phase 2 Clinical | Bristol-Myers Squibb Company | Solid tumours | Details |
Mupadolimab | CPX-006; COR-004 (Corvus Pharmaceuticals); CPI-006 | Phase 2 Clinical | Corvus Pharmaceuticals Inc | Papillomavirus Infections; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms; Lymphoma, Non-Hodgkin; Endometrial Neoplasms; Colorectal Neoplasms; Sarcoma; Prostatic Neoplasms, Castration-Resistant; Urinary Bladder Neoplasms; Ovarian Neoplasms; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Coronavirus Disease 2019 (COVID-19); Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Head and Neck Neoplasms; Solid tumours | Details |
Dresbuxelimab | AK-119 | Phase 2 Clinical | Akeso Pharmaceuticals Inc | Solid tumours; Coronavirus Disease 2019 (COVID-19); Idiopathic Pulmonary Fibrosis; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung | Details |
S-095024 | S-095024; S095024 | Phase 2 Clinical | Institut De Recherches Internationales Servier, Servier Bio-Innovation LLC, Regeneron Pharmaceuticals Inc | Carcinoma, Non-Small-Cell Lung | Details |
HB-0045 | HB-0045; HB0045 | Phase 2 Clinical | Shanghai Huaota Biopharmaceutical Co Ltd, HuaBo Biopharm Co Ltd | Solid tumours | Details |
JAB-BX102 | JAB-BX102 | Phase 2 Clinical | Jacobio Pharmaceuticals Co Ltd | Solid tumours | Details |
PT-199 | PT-199 | Phase 2 Clinical | Phanes Therapeutics Inc | Solid tumours; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung | Details |
LY-3475070 | LY-3475070 | Phase 1 Clinical | Eli Lilly And Company | Neoplasms | Details |
Anti-CD73 monoclonal antibody (Bristol-Myers Squibb) | Phase 1 Clinical | Bristol-Myers Squibb Company | Neoplasms | Details | |
Uprevstobart | INCA-00186 | Phase 1 Clinical | Incyte Corp Ltd | Solid tumours; Squamous Cell Carcinoma of Head and Neck; Gastrointestinal Neoplasms | Details |
AK-137 | AK137; AK-137 | Phase 1 Clinical | Zhongshan Akeso Biopharma Co Ltd | Neoplasms | Details |
68GA-DOTA-dPNE | 68GA-DOTA-dPNE | Phase 1 Clinical | Peking Union Medical College Hospital | Breast Neoplasms | Details |
HB-0052 | HB-0052; HB0052 | Phase 1 Clinical | Shanghai Huaota Biopharmaceutical Co Ltd | Solid tumours | Details |
BPI-472372 | BPI-472372 | Phase 1 Clinical | Betta Pharmaceuticals Co Ltd | Solid tumours | Details |
BB-1709 | BB-1709 | Phase 1 Clinical | Bliss Biopharmaceutical (Hangzhou) Co Ltd | Solid tumours | Details |
PM-1015 | PM1015; PM-1015 | Phase 1 Clinical | Solid tumours | Details | |
AK-131 | AK-131 | Phase 1 Clinical | Zhongshan Akeso Biopharma Co Ltd | Solid tumours; Neoplasms | Details |
IBI-325 | IBI-325 | Phase 1 Clinical | Innovent Biologics(Suzhou) Co Ltd | Solid tumours | Details |
BR-101 | BR101; BR-101 | Phase 1 Clinical | BioRay Pharmaceutical Co Ltd | Solid tumours | Details |
CB-708 | ATG-037; ATN-037; CB-708; CB708 | Phase 1 Clinical | Calithera Biosciences Inc | Solid tumours; Neoplasms; Carcinoma, Non-Small-Cell Lung; Melanoma | Details |
HLX-23 | HLX-23 | Phase 1 Clinical | Shanghai Henlius Biologics Co Ltd | Solid tumours; Lymphoma | Details |
ORIC533 | ORIC-533 | Phase 1 Clinical | Oric Pharmaceuticals Inc | Multiple Myeloma; Neoplasm Metastasis | Details |
IPH-5301 | IPH-5301 | Phase 1 Clinical | Innate Pharma | Solid tumours; Ovarian Neoplasms; Esophageal Neoplasms; Stomach Neoplasms; Neoplasms; Pancreatic Neoplasms; Breast Neoplasms; Metastatic breast cancer; Endometrial Neoplasms; Lung Neoplasms; Neoplasm Metastasis | Details |
HBM-1007 | HBM1007; R 1007; HBM 1007; HBM-1007 | Phase 1 Clinical | Harbour Biomed | Solid tumours; Neoplasms | Details |
ABSK-051 | ABSK051 | Phase 1 Clinical | ABbisko Therapeutics Co Ltd | Solid tumours; Neoplasms | Details |
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