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Your Position: Home > CD47

CD47

Brief Information

Name:Cluster of differentiation 47
Target Synonym:MER6,CD47,Leukocyte surface antigen CD47,CD47 Molecule,Antigenic Surface Determinant Protein OA3,CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer),Antigen Identified By Monoclonal Antibody 1D8,Integrin Associated Protein,Rh-Related Antigen,CD47 Glycoprotein,IAP,Integrin-Associated Signal Transducer,Protein MER6,OA3,CD47 Antigen,Integrin-Associated Protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:57
Lastest Research Phase:Phase 3 Clinical

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
CD47 Monoclonal Antibody Monospecific antibody Oncology/Cancer Advanced solid tumor,Advanced hematological tumor IND Global

Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
CD7-C82F3 Cynomolgus / Rhesus macaque Biotinylated Cynomolgus / Rhesus macaque CD47 Protein, Fc,Avitag™ (MALS verified)
CD7-C82F3-structure
CD7-C82F3-sds
MBS-K080 Human APC-labeled Human CD47-coupled Magnetic Beads
CD7-C82E3 Cynomolgus / Rhesus macaque Biotinylated Cynomolgus / Rhesus macaque CD47 Protein, His,Avitag™
CD7-C82E3-structure
CD7-C82E3-sds
EP-160 Human CD47 : SIRP gamma [Biotinylated] Inhibitor Screening ELISA Kit
CD7-M82F5 Mouse Biotinylated Mouse CD47 Protein, Fc,Avitag™ (MALS verified)
CD7-M82F5-structure
CD7-M82F5-sds
MBS-K059 Human PE-labeled Human CD47-coupled Magnetic Beads
EP-152 Human CD47 [Biotinylated] : SIRP alphaV2 Inhibitor Screening ELISA Kit
EP-138 Human CD47 [Biotinylated] : SIRP alpha Inhibitor Screening ELISA Kit
MBS-K023 Human Human CD47-coupled Magnetic Beads
CD7-H82A3 Human Biotinylated Human CD47 Protein, Mouse IgG2a Fc,Avitag™ (MALS verified)
CD7-H82A3-structure
CD7-H82A3-sds
CD7-HF2H3 Human FITC-Labeled Human CD47 Protein, His Tag
CD7-HF2H3-structure
CD7-HF2H3-sds
CD7-M82E4 Mouse Biotinylated Mouse CD47 Protein, His,Avitag™ (MALS verified)
CD7-M82E4-structure
CD7-M82E4-sds
CD7-C52H5 Canine Canine CD47 Protein, His Tag
CD7-C52H5-structure
CD7-C52H5-sds
CD7-H522a Human Human CD47 Protein, His Tag, low endotoxin
CD7-H522a-structure
CD7-H522a-sds
CD7-H5251 Human Human CD47 Protein, Llama IgG2b Fc Tag, low endotoxin
CD7-H5251-structure
CD7-H5251-sds
CD7-M525a Mouse Mouse CD47 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-M525a-structure
CD7-M525a-sds
CD7-M522b Mouse Mouse CD47 Protein, His Tag (MALS verified)
CD7-M522b-structure
CD7-M522b-sds
CD7-C52H1 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD47 Protein, His Tag
CD7-C52H1-structure
CD7-C52H1-sds
CD7-HA2E9 Human Unconjugated Human CD47 Protein, His,Avitag™ (HPLC verified)
CD7-HA2E9-structure
CD7-HA2E9-sds
CD7-HA2E9-hplc
CD7-H82E9 Human Biotinylated Human CD47 Protein, His,Avitag™ (MALS verified)
CD7-H82E9-structure
CD7-H82E9-sds
CD7-R5257 Rabbit Rabbit CD47 Protein, Fc Tag
CD7-R5257-structure
CD7-R5257-sds
CD7-R5256 Rat Rat CD47 Protein, Fc Tag
CD7-R5256-structure
CD7-R5256-sds
CD7-H52A5 Human Human CD47 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H52A5-structure
CD7-H52A5-sds
CD7-C5252 Cynomolgus / Rhesus macaque Cynomolgus / Rhesus macaque CD47 Protein, Fc Tag
CD7-C5252-structure
CD7-C5252-sds
CD7-M5251 Mouse Mouse CD47 Protein, Fc Tag (MALS verified)
CD7-M5251-structure
CD7-M5251-sds
CD7-H82F6 Human Biotinylated Human CD47 Protein, Fc,Avitag™ (MALS verified)
CD7-H82F6-structure
CD7-H82F6-sds
CD7-H5227 Human Human CD47 Protein, His Tag (MALS verified)
CD7-H5227-structure
CD7-H5227-sds
CD7-H5256 Human Human CD47 Protein, Fc Tag (MALS verified)
CD7-H5256-structure
CD7-H5256-sds
ACRO Quality

Part of Bioactivity data

CD7-H82E9-Cell-based assay
CD47 FACS

FACS assay shows that Biotinylated Human CD47, His,Avitag (Cat. No. CD7-H82E9) can bind to ACHN cell expressing human SIRP-a. The concentration of CD47 used is 10 μg/mL (Routinely tested).

Protocol
CD7-H82E9-Cell-based assay
CD47 FACS

FACS analysis shows that the binding of Human CD47 to ACHN expressing SIRP-a was inhibited by increasing concentration of neutralizing SIRP-a antibody. The concentration of Human CD47 used is 20 μg/mL. IC50=9.334 μg/mL

Protocol
CD7-M522b-SPR
CD47 SPR

Mouse SIRP alpha, His Tag (Cat. No. SIA-M52H4) immobilized on CM5 Chip can bind Mouse CD47, His Tag (Cat. No. CD7-M522b) with an affinity constant of 2.52 µM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
CD7-C52H1-SPR
CD47 SPR

Anti-CD47 Mab (Human IgG4) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Cynomolgus/Rhesus macaque CD47, His Tag (Cat. No. CD7-C52H1) with an affinity constant of 1.8 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Customer Reviews

Synonym Name

CD47,MER6,IAP,OA3

Background

Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

Clinical and Translational Updates

Related Molecule

SIRP alpha

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